Task 6 : Multicentric and Intergrated platform development

The aim of this task is to develop a multicentric (Brest-Poitiers-Tours-Orleans) and integrated platform (from channel activities to cell migration) allowing the scientific community to screen for modulators of TRPC, Orai / STIM and KCa channels using patch clamp technique, calcium fluorescent based assays and 2D/3D cell migration assays. Drug-channels interactions are observed using mass spectrometry (Orleans). The overall goal of this platform is to discover new ion channel pharmacological modulators (targeting ion channels involved in cell migration and the development of metastases) that can potentially be used in drug-based cancer therapy.