Different network actors are involved in this publication:
"New Disaccharide-Based Ether Lipids as SK3 Ion Channel Inhibitors. - Berthe W1,2, Sevrain CM1,2, Chantôme A3,2, Bouchet AM3,2, Gueguinou M3,2, Fourbon Y3,2, Potier-Cartereau M3,2, Haelters JP1,2, Couthon-Gourvès H1,2, Vandier C3,2, Jaffrès PA4,5 ChemMedChem. 2016 Jun 9."
Ohmline is a glyco-glycero-ether lipid that was previously designed in our research groups. This compounds is a selective modulator of SK3 ion channel. This ion channel is implicated in the migration of cancer cells. In a murine model of breast cancer the inhibition of SK3 with ohmline reduced bone and lung metastases. In this article we report the synthesis of new analogues of ohmline with structural modifications at the disaccharide moiety. The new analogues were evaluated as inhibitor of SK3 channel. This work led to the conclusion that the structure of the dissacharide moiety can deeply impact the inhibition properties and that compound 2 possessed similar inhibition properties than ohmline.
1 Université de Brest, CEMCA, CNRS UMR 6521, IBSAM, 6 Avenue Le Gorgeu, 29238, Brest, France..
2 Network "Ion Channels and Cancer - Canceropole Grand Ouest", (IC-CGO), France.
3 INSERM, UMR 1069, Université François Rabelais, Tours, 37032, France.
4 Université de Brest, CEMCA, CNRS UMR 6521, IBSAM, 6 Avenue Le Gorgeu, 29238, Brest, France.
5 Network "Ion Channels and Cancer - Canceropole Grand Ouest", (IC-CGO), France.