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"Alkyl ether lipids, ion channels and lipid raft reorganization in cancer therapy. - Jaffrès PA1, Gajate C2, Bouchet AM3, Couthon-Gourvès H1, Chantôme A3, Potier-Cartereau M3, Besson P3, Bougnoux P4, Mollinedo F2, Vandier C5. Pharmacol Ther. 2016 Jun 8."
More information:
This review article is dedicated to ether-lipids that are forming a class of anti-cancer agents and that can interact with plasma membrane leading to trigger apoptosis or to reduce cancer cell migration. In this article a first part is dedicated to the pro apoptotic Edelfosine and to its mechanism of action that starts from interactions with the plasma membrane to trigger apoptosis. The second part is focused on Ohmline (a more recently discovered molecule - 2011) which is an efficient and selective modulator of SK3 ion channel. This action, can inhibit the formation of bone metastasis in a murine model of metastatic breast cancer. In this article, a structure-activity relationship is presented for both compounds (Edelfosine and Ohmline) and in terms of mechanism of action, a reorganization of lipid raft appeared as an essential step.
1 CEMCA, UMR CNRS 6521, IBSAM, Université de Brest, 6, Avenue V. Le Gorgeu, 29238 Brest Cedex 3, France; Network "Ion channels and Cancer-Canceropole Grand Ouest", (IC-CGO), France. Electronic address: http://www.ic-cgo.fr.
2 Laboratory of Cell Death and Cancer Therapy, Department of Cellular and Molecular Medicine, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), C/Ramiro de Maeztu 9, E-28040 Madrid, Spain.
3INSERM/University of Tours U1069, Nutrition-Croissance et Cancer (N2C), F-37032 Tours, France; Network "Ion channels and Cancer-Canceropole Grand Ouest", (IC-CGO), France. Electronic address: http://www.ic-cgo.fr.
4 INSERM/University of Tours U1069, Nutrition-Croissance et Cancer (N2C), F-37032 Tours, France; Centre HS Kaplan, CHU Bretonneau, Tours F-37032, France; Network "Ion channels and Cancer-Canceropole Grand Ouest", (IC-CGO), France. Electronic address: http://www.ic-cgo.fr.
5 INSERM/University of Tours U1069, Nutrition-Croissance et Cancer (N2C), F-37032 Tours, France; Network "Ion channels and Cancer-Canceropole Grand Ouest", (IC-CGO), France. Electronic address: christophe.vandier@univ-tours.fr.
